Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

by Hašková, Pavlína, Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Jirkovská, Anna, Franz, Katherine J, Kovaříková, Petra, Šimůnek, Tomáš, Dr
Published in Toxicology (Amsterdam) (2016)

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products

by Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Hašková, Pavlína, Jirkovská, Anna, Roh, Jaroslav, Wang, Qin, Franz, Katherine J, Kovaříková, Petra, Šimůnek, Tomáš
Published in Toxicology (Amsterdam) (2016)

Structure–Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities

by Hrušková, Kateřina, Potůčková, Eliška, Opálka, Lukáš, Hergeselová, Tereza, Hašková, Pavlína, Kovaříková, Petra, Šimůnek, Tomáš, Vávrová, Kateřina
Published in Chemical research in toxicology (2018-06-18)

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

by Potůčková, Eliška, Roh, Jaroslav, Macháček, Miloslav, Sahni, Sumit, Stariat, Ján, Šesták, Vít, Jansová, Hana, Hašková, Pavlína, Jirkovská, Anna, Vávrová, Kateřina, Kovaříková, Petra, Kalinowski, Danuta S, Richardson, Des R, Šimůnek, Tomáš
Published in PloS one (2015)

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress

by Filipský, Tomáš, Říha, Michal, Hašková, Pavlína, Pilařová, Veronika, Nováková, Lucie, Semecký, Vladimír, Vávrová, Jaroslava, Holečková, Magdaléna, Palicka, Vladimir, Šimůnek, Tomáš, Hrdina, Radomír, Mladěnka, Přemysl
Published in Redox report : communications in free radical research (2017-03-04)

Chronic Anthracycline Cardiotoxicity: Molecular and Functional Analysis with Focus on Nuclear Factor Erythroid 2-Related Factor 2 and Mitochondrial Biogenesis Pathways

by Jirkovský, Eduard, Popelová, Olga, Křiváková-Staňková, Pavla, Vávrová, Anna, Hroch, Miloš, Hašková, Pavlína, Brčáková-Doleželová, Eva, Mičuda, Stanislav, Adamcová, Michaela, Šimůnek, Tomáš, Červinková, Zuzana, Geršl, Vladimír, Štěrba, Martin
Published in The Journal of pharmacology and experimental therapeutics (2012-11)

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties

by Potůčková, Eliška, Hrušková, Kateřina, Bureš, Jan, Kovaříková, Petra, Špirková, Iva A, Pravdíková, Kateřina, Kolbabová, Lucie, Hergeselová, Tereza, Hašková, Pavlína, Jansová, Hana, Macháček, Miloslav, Jirkovská, Anna, Richardson, Vera, Lane, Darius J R, Kalinowski, Danuta S, Richardson, Des R, Vávrová, Kateřina, Šimůnek, Tomáš
Published in PloS one (2014)

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

by Říha, Michal, Hašková, Pavlína, Martin, Jan, Filipský, Tomáš, Váňová, Kateřina, Vávrová, Jaroslava, Holečková, Magdalena, Homola, Pavel, Vítek, Libor, Palicka, Vladimír, Šimůnek, Tomáš, Mladěnka, Přemysl
Published in Oxidative medicine and cellular longevity (2015-12-14)

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity

by HaA kova, PavliNa, KovaAikova, Petra, Koubkova, Lucie, Vavrova, Anna, Mackova, EliA Ka, A imA[macron]nek, TomaA
Published in Free radical biology & medicine (2011-02-15)

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action

by Macková, Eliška, Hrušková, Kateřina, Bendová, Petra, Vávrová, Anna, Jansová, Hana, Hašková, Pavlína, Kovaříková, Petra, Vávrová, Kateřina, Šimůnek, Tomáš
Published in Chemico-biological interactions (2012-05-30)

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity

by HASKOVA, Pavlina, KOUBKOVA, Lucie, VAVROVA, Anna, MACKOVA, Eliska, HRUSKOVA, Katefina, KOVARIKOVA, Petra, VAVROVA, Kateřina, SIMUNEK, Tomas
Published in Toxicology (Amsterdam) (2011)

The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity

by Mladĕnka, Pr̆emysl, Kalinowski, Danuta S, Hašková, Pavlína, Bobrovová, Zuzana, Hrdina, Radomír, Šimůnek, Tomáš, Nachtigal, Petr, Semecký, Vladimír, Vávrová, Jaroslava, Holečková, Magdaléna, Palicka, Vladimir, Mazurová, Yvona, Jansson, Patric J, Richardson, Des R
Published in Chemical research in toxicology (2009-01-19)

HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers

by KOVARIKOVA, Petra, VAVROVA, Katerina, TOMALOVA, Katerina, SCHÖNGUT, Michal, HRUSKOVA, Katerina, HALASOVA, Pavlina, KLIMES, Jiri
Published in Journal of pharmaceutical and biomedical analysis (2008)

Antiproliferative effects of selenium compounds in colon cancer cells: Comparison of different cytotoxicity assays

by Schröterová, Ladislava, Králová, Věra, Voráčová, Adéla, Hašková, Pavlína, Rudolf, Emil, Červinka, Miroslav
Published in Toxicology in vitro (2009)

Direct administration of rutin does not protect against catecholamine cardiotoxicity

by Mladěnka, Přemysl, Zatloukalová, Libuše, Šimůnek, Tomáš, Bobrovová, Zuzana, Semecký, Vladimír, Nachtigal, Petr, Hašková, Pavlína, Macková, Eliška, Vávrová, Jaroslava, Holečková, Magdaléna, Palicka, Vladimir, Hrdina, Radomír
Published in Toxicology (Amsterdam) (2008)

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

by Jirkovská-Vávrová, Anna, Roh, Jaroslav, Len ová-Popelová, Olga, Jirkovský, Eduard, Hrušková, Kate ina, Pot ková-Macková, Eliška, Jansová, Hana, Hašková, Pavlína, Martinková, Pavla, Eisner, Tomáš, Kratochvíl, Marek, Š s, Jan, Machá ek, Miloslav, Vostatková-Tichotová, Lucie, Geršl, Vladimír, Kalinowski, Danuta S, Muller, Mark T, Richardson, Des R, Vávrová, Kate ina, Št rba, Martin, Šim nek, Tomáš
Published in Toxicology research (Cambridge) (2015-06-22)

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications

by Hrušková, Kateřina, Potůčková, Eliška, Hergeselová, Tereza, Liptáková, Lucie, Hašková, Pavlína, Mingas, Panagiotis, Kovaříková, Petra, Šimůnek, Tomáš, Vávrová, Kateřina
Published in European journal of medicinal chemistry (2016-09-14)

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity

by VAVROVA, Anna, POPELOVA, Olga, STERBA, Martin, JIRKOVSKY, Eduard, HASKOVA, Pavlina, MERTLIKOVA-KAISEROVA, Helena, GERSL, Vladimír, SIMUNEK, Tomáš
Published in Archives of toxicology (2010-11-03)

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

by Novotná, Eva, Waisser, Karel, Kuneš, Jiří, Palát, Karel, Skálová, Lenka, Szotáková, Barbora, Buchta, Vladimír, Stolaříková, Jiřina, Ulmann, Vít, Pávová, Marcela, Weber, Jan, Komrsková, Jitka, Hašková, Pavlína, Vokřál, Ivan, Wsól, Vladimír
Published in Archiv der Pharmazie (Weinheim) (2017-08)

Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells

by Vavrova, Anna, Jansova, Hana, Mackova, Eliska, Machacek, Miloslav, Haskova, Pavlina, Tichotova, Lucie, Sterba, Martin, Simunek, Tomas
Published in PloS one (2013)