Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients.

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any sign...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of Inflammation pp. 1 - 10
Main Authors:
Format: Article
Published: Hindawi Limited, 1/6/2021
Subjects:
Online Access:Go to the source
Tags: Add Tag
Be the first to tag this record!
fields Array ( [recordID] => 1 )
Array ( )
http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=147943908&site=ehost-live
Array ( [@attributes] => Array ( [shortDbName] => a9h [uiTerm] => 147943908 [longDbName] => Academic Search Complete [uiTag] => AN ) [controlInfo] => Array ( [bkinfo] => Array ( ) [jinfo] => Array ( [jid] => Array ( [0] => 09629351 [1] => 36J ) [jtl] => Mediators of Inflammation [issn] => 09629351 [maglogo] => Y ) [pubinfo] => Array ( [dt] => 1/6/2021 [pub] => Hindawi Limited ) [artinfo] => Array ( [ui] => Array ( [0] => 147943908 [1] => 10.1155/2021/8831659 ) [ppf] => 1 [ppct] => 9 [formats] => Array ( [fmt] => Array ( [0] => Array ( [@attributes] => Array ( [type] => T ) ) [1] => Array ( [@attributes] => Array ( [type] => P [size] => 828KB ) ) ) ) [tig] => Array ( [atl] => Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients. ) [aug] => Array ( [au] => Array ( [0] => Franeková, Janka [1] => Protuš, Marek [2] => Kieslichová, Eva [3] => Březina, Aleš [4] => Komrsková, Jitka [5] => Vymětalík, Jiří [6] => Jabor, Antonín ) [affil] => Array ( [0] => Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic [1] => Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic [2] => Department of Anesthesiology, Resuscitation, and Intensive Care, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic [3] => First Faculty of Medicine, Charles University, Kateřinská 1660/32, 121 08 Prague 2, Czech Republic [4] => Department of Anesthesiology and Resuscitation, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic ) ) [su] => Array ( [0] => LEUCOCYTES [1] => SEPSIS [2] => BIOMARKERS [3] => CALCITONIN [4] => GLOBULINS ) [sug] => Array ( [subj] => Array ( [0] => LEUCOCYTES [1] => SEPSIS [2] => BIOMARKERS [3] => CALCITONIN [4] => GLOBULINS ) ) [ab] => Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx < 2380 vs. non ‐ Tx < 1368 ng / L , p < 0.05 ; procalcitonin: <28.0 vs. 3.49 μg/L, p < 0.05). In contrast, CRP and IL-6 were lower in the Tx group (CRP: Tx < 84.2 vs. non ‐ Tx < 229 mg / L , p < 0.05 ; IL-6: <71.2 vs. 317 ng/L, p < 0.05). Decreases in CRP and IL-6 were found for all immunosuppressants, and procalcitonin was increased after antithymocyte globulin and corticosteroids. Negligible changes were found for white blood cells. Different responses of presepsin, procalcitonin, CRP, and IL-6 were therefore found in patients without any infectious complications after major surgery or transplantation. Immunosuppression decreased significantly IL-6 and CRP in comparison to non-Tx patients, while procalcitonin was increased after corticosteroids and antithymocyte globulin only. Cautious interpretation of sepsis biomarkers is needed in the early posttransplant period. This work was conducted as a noninterventional (nonregistered) study. [pubtype] => Academic Journal [doctype] => Article [src] => R ) [language] => English [refInfo] => Array ( ) [copyright] => Array ( [@attributes] => Array ( [flag] => Y ) [custom] => Copyright of Mediators of Inflammation is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. [item] => Mediators of Inflammation [holder] => Hindawi Limited [dt] => Array ( [@attributes] => Array ( [year] => 2021 ) ) ) [holdings] => Array ( [@attributes] => Array ( [islocal] => N ) ) ) )